Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel



The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips).


At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology).
The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 +/- 30.5 nm.
Besides, PTX was efficiently encapsulated in Lips, 94.5 +/- 3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX.
More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX.
As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.


Title: Development and In Vitro Evaluation of Liposomes Using Soy Lecithin to Encapsulate Paclitaxel
Authors: Nguyen Thi Lan
Nguyen Thi Hiep
Nguyen Dai Hai
Keywords: RESISTANT LUNG-CANCER
DRUG-DELIVERY
NANOPARTICLES
DOXORUBICIN
EFFICACY
THERAPY
RELEASE
GROWTH
PEG
Issue Date: 2017
Publisher: HINDAWI LTD, ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
Citation: ISIKNOWLEDGE
Abstract: The formulation of a potential delivery system based on liposomes (Lips) formulated from soy lecithin (SL) for paclitaxel (PTX) was achieved (PTX-Lips). At first, PTX-Lips were prepared by thin film method using SL and cholesterol and then were characterized for their physiochemical properties (particle size, polydispersity index, zeta potential, and morphology). The results indicated that PTX-Lips were spherical in shape with a dynamic light scattering (DLS) particle size of 131 +/- 30.5 nm. Besides, PTX was efficiently encapsulated in Lips, 94.5 +/- 3.2% for drug loading efficiency, and slowly released up to 96 h, compared with free PTX. More importantly, cell proliferation kit I (MTT) assay data showed that Lips were biocompatible nanocarriers, and in addition the incorporation of PTX into Lips has been proven successful in reducing the toxicity of PTX. As a result, development of Lips using SL may offer a stable delivery system and promising properties for loading and sustained release of PTX in cancer therapy.
Description: TNS07016 ; INTERNATIONAL JOURNAL OF BIOMATERIALS Article Number: 8234712 Published: 2017
URI: http://repository.vnu.edu.vn/handle/VNU_123/28833
ISSN: 1687-8787
1687-8795
Appears in Collections:Bài báo của ĐHQGHN trong Web of Science


Nhận xét

Bài đăng phổ biến